cancer cell cycles
The benefits of green tea – Cancer
The compounds of green tea is believed to help against cancer
The catechins
A sheet of green tea contains catechins, which are the elements that give a bitter taste to tea.
EGCG (epigallocatechin gallate) is 10% -50% of total catechins green tea. Given the special stereochemical structure, EGCG possesses much of the antioxidants called catechins that other documents found in green tea and plays a important role in preventing cancer and cardiovascular disease. ECGC oxidized eliminate free radicals in the body that prevents damage to cells and DNA. The EGCG's antioxidant properties are considered as more than 100 times more effective than vitamin C and 25 times more effective than vitamin E. (Http: / / www.herbs-tech.com/product/egcg.asp)
Flavonoids
Flavonoids are plant pigments, which are the brightly colored chemical constituents in most fruits and vegetables. Flavonoids are essential for the treatment of vitamin C and are required to maintain the capillary walls. They can help protect against infection and deficiency can carry a tendency to bruise easily.
Health Benefits
Reduce Cancer Risk
Provisional components: flavonoids and catechins
How:
Carcinogens are cancer-causing agents. Phytochemicals may prevent the formation carcinogens. Flavonoids are a class of phytochemicals found in green tea. Experimental studies have shown that tea and tea polyphenols have anti-cancer properties against breast cancer. ¹
Studies also suggest that ECGC may reduce cancer risk. ²
A population case-control breast cancer among Chinese women, Japanese and Filipinos in Los Angeles County suggested an inverse relationship between green tea consumption and development breast cancer. ³ similar study has been done with women in Italy has shown a similar inverse relationship. ⁴
The results of animal studies and possible mechanisms of cancer inhibitor could be applicable to human cancer prevention. The results and possible applications are examined in a study by Yang CS et al. 2000.
"Free radicals attack healthy cells, altering their DNA, allowing tumors [sic] to grow. Antioxidants are substances that inhibit the oxidation process and act as protective agents. Antioxidants Research is underway to examine the role of antioxidants to reduce the risk of developing cancer. "
(Http: / / cancer.stanford.edu / info / nutritionAndCancer / reduceRisk /)
Catechins in tea Green is known for its antioxidant properties. ⁶
(Http: / / www.herbs-tech.com/product/egcg.asp)
Studies
¹ Can-Lan Sun Jian-Min Yuan, Woon-Puay Koh, and Mimi C. Yu Green tea, black tea and breast cancer risk: a meta-analysis of epidemiological studies Carcinogenesis 2006 27 (7) :1310-1315
Maryam R. ² Sartippour, Zhi-Ming Shao, David Heber Perrin Beatty, Liping Zhang, Liu Canhui, Ellis Lee Liu, Wen, Vay Liang Go N. May green tea inhibits Brooks vascular endothelial growth factor vascular (VEGF) in the Journal of induction of human breast cancer cells nutrition. 2002 132:2307-2311
Anna ³ H. Wu, Mimi C. Yu, Chiu-Chen Tseng, Jean Hankin, Malcolm C. Pike. Green tea and risk of breast cancer among Asian Americans. International Journal of Cancer. September 10 106 (4) :574-579.
Cristina Bosetti, Spertini Luana, Maria Patrizia Parpinel Gnagnarella, Pagon Lagiou, Eva Negri, Silvia Franceschi, Maurizio Montella, Julie Peterson, Johanna Dwyer Attilio Giacosa and Carlo La Vecchia flavonoids and risk of breast cancer in Italy. Cancer Prevention April 2005 Vol. 14, 805-808,
S. Chung Jee Y. Yang Chung, Guang-yu Yang, K. Saranjit Chhabra and Lee Jung-Mao. Tea and tea polyphenols in cancer prevention. Journal of Nutrition. 2000, 130:472 .. S-478S
Balz Frei and Jane V. ⁶ Higdon antioxidant activity of tea polyphenols Live: Results from animal studies Journal of Nutrition October 2003 133:3275 S-3284
Canned tumors
intermediate component: catechins (EGCG and ECG)
How:
EGCG inhibits tumor growth by inducing apoptosis ¹ (process of self-destruction of the cell), inhibition of cell growth and disrupt cell cycle. ²
EGCG inhibits the growth of cancer cells, ECG, in some cases it is considered more effective than the punishment that the growth of EGCG. ³ Green tea contains catechins both.
Angiogenesis is the growth of new blood vessels from preexisting capillaries. This process is involved in the development of cancer. Angiogenesis is necessary for tumor growth, providing nutrients and oxygen to tumor growth. One possible mechanism by which green tea can prevent cancer is through the inhibition of angiogenesis. ⁴
Researchers at the University of Murcia in Spain (UMU) and the John Innes Centre (JIC) in Norwich have shown that EGCG prevents cancer cells by inhibiting a specific enzyme.
"The research is published in the International Journal of Cancer Research.
Studies
L. Rajesh ¹ Thangapazham, Anoop K. Singh, Anuj Sharma, James Warren, P. Jaya Radha and K. Gaddipati Maheshwari. Green tea polyphenols and epigallocatechin gallate inhibits proliferation component of human tumor cells in vitro and in vivo. Cancer Lett. Epub March 3rd, 2006. Vergote D, Cren-Olive C, Chopin V, Toillon AR., Rolando C., H. Hondermarck, Bourhis XL (-)-epigallocatechin (GC) of green tea induces apoptosis of human breast cancer, but not their normal counterparts. Res Treat Breast Cancer. 2002 76, 3:195-201
² Vaqar M. Adhami, Nihal Ahmad and Hasan Mukhtar Molecular Targets for tea Green in preventing prostate cancer The Journal of Nutrition (July 2003) 133:2417 S-2424
N Ahmad, DK Feyes, Nieminen AL, Agarwal R and Mukhtar H component Green tea epigallocatechin-3-gallate and induction of apoptosis and cell cycle arrest in human carcinoma cells Journal of the National Cancer Institute 1997 Vol 89, 1881-1886
Bigelow RL, Cardelli JA. Green tea catechins, (-)-epigallocatechin-3-gallate (EGCG) and (-)-epicatechin-3-gallate (ECG), inhibit HGF / MET signaling in immortalized and tumorigenic breast epithelial cells. Oncogene. 2006 25, 13:1922-30
³ Mepur H. Ravindranath, S. Thiruverkadu Saravanan, C. Monteclaro Clarence, Naftali Presser, Xing Ye, R. Selvan and epicatechin Senthamil Stanley Brosman purified green tea (Camellia sinensis) differentially suppress growth lines of gender-dependent human cancer cells based evid Complement Alternat Med June 2006; 3:237-47
Rodriguez ⁴ SK, Guo W, Liu L, Band MA, Paulson EK, Meydani M. catechins in green tea, epigallocatechin-3-gallate, inhibits vascular endothelial growth factor angiogenic signaling by disrupting the formation of a receptor complex. International Journal of Cancer 2006; 118 (7) :1635-44. Jian-Min Yuan, Woon-Puay Koh, Sun may Lan, Hin-Peng Lee and Mimi C. Yu Green tea intake, the polymorphism of the ACE gene and the risk of breast cancer in Chinese women in Singapore. Carcinogenesis. 2005 26, 8:1389-94,
Help for the success of cancer treatments
Components: catechin (EGCG)
How:
Radiation treatment Cancer can promote angiogenesis (the formation of new blood vessels from preexisting capillaries to provide nutrients and oxygen to growth tumor) ECGC Catechins have anti-angiogenic properties which may help to counteract this. ¹
Studies
¹ B Annabi, YT Lee, C Martel, a Pilorget, JP Bahary, Beliveau R radiation-induced tubulogenesis in endothelial cells is offset by the antiangiogenic properties of tea polyphenols Green (-) epigallocatechin-3-gallate. Journal of Cancer Biology and Therapy 2003 Nov-Dec, 2 (6) :642-9
About the Author
Hazel tan is the Managing Director of China’s Secret Teas.
China’s Secret was created to share the authentic Chinese tea experience with the West.
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